Comparison of BACTEC 9120 and Conventional Blood Culture Systems for Isolation of Microorganisms from Blood and Other Sterile Body Fluids

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Bloodstream infectious diseases are prevalent in children and adults. Rapid
and accurate diagnosis of bloodstream infections primary based on conventional culture
results, which saves time and prevents empiric treatment. The aim of this study was to
compare the results of BACTEC 9120 and conventional culture systems, on blood specimens
collected from three university affiliated hospitals in Tehran, Iran. BACTEC 9120 and
conventional methods were used for isolation of microorganism from specimens including
blood and other body fluid samples collected from patients hospitalized in the selected
hospitals during the study period, from April to June 2009. Time for positive and negative
results and hospital charge were estimated for the two culture methods. In total 747
specimens were possessed by BACTEC 9120 systems and 787 by conventional method.
Patients aged between 3 days and 8 years old, (mean 11.4±21.9 years); 52% of patients
were male and 48% female; Out of 747 specimens were possessed by BACTEC 9120
system, 26% (196/747) and from 787 specimens cultured by conventional method 5% (49/
787) were positive (p<0.05). Hospital stay was 13.8 ± 12.9 days in BACTEC 9120 and 17.9
± 14.9 days in Conventional method,(p<0.05) respectively. Time for positivity by BACTEC
system was 3.8 ± 1.1 Days and 5.9 ± 2.5 days in conventional method.(p<0.05), treatment
response showed 1.8 day earlier result in patients that their specimens were processed
by BACTEC 9120 system . Death rate in BACTEC 9120 method was 6% and 11% in
Conventional method. (p>0.05).In conclusion implementation of BACTEC system for
microbiologic detection of pathogens decreases the admission time and early diagnosis
and treatment results are cost effective for patient management and prevention of antibiotic
resistance.

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